T-type calcium channel Inhibitor

T-type calcium channel Inhibitors (24):

Cat. No.	Product Name	Effect	Purity

HY-B0166

L-Ascorbic acid	Inhibitor	99.97%
L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Ca_v3.2 channels with an IC₅₀ of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor. L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells.

HY-B0166A

L-Ascorbic acid sodium salt	Inhibitor	99.97%
L-Ascorbic acid sodium salt (Sodium ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid sodium salt selectively inhibits Ca_v3.2 channels with an IC₅₀ of 6.5 μM. L-Ascorbic acid sodium salt is also a collagen deposition enhancer and an elastogenesis inhibitor.

HY-15553A

Mibefradil dihydrochloride	Inhibitor	≥98.0%
Mibefradil dihydrochloride (Ro 40-5967 dihydrochloride) is a calcium channel blocker with moderate selectivity for T-type Ca²⁺ channels (IC₅₀s of 2.7 μM and 18.6 μM for T-type and L-type currents, respectively).

HY-50722

NNC 55-0396	Inhibitor	≥99.0%
NNC 55-0396 is a highly selective T-type calcium channel blocker with an IC₅₀ value of 6.8 μM for Cav3.1 T-type channels. NNC 55-0396 can be used for the research of neurological disease research.

HY-B0358A

Flunarizine dihydrochloride	Inhibitor	99.87%
Flunarizine dihydrochloride is a potent dual Na⁺/Ca²⁺ channel (T-type) blocker. Flunarizine dihydrochloride is a D₂ dopamine receptor antagonist. Flunarizine dihydrochloride shows anticonvulsive and antimigraine activity, and peripheral vasodilator effects.

HY-17403

Manidipine dihydrochloride	Inhibitor	99.91%
Manidipine dihydrochloride is a third-generation, lipophilic, orally active and highly vasoselective calcium channel antagonist (IC₅₀ = 2.6 nM in guinea-pig ventricular cells) and acts as an antihypertensive agent. Manidipine effectively reduces blood pressure as well as improving insulin sensitivity, renal protection, and antiatherosclerotic activity. Manidipine also exerts anti-inflammatory activity mediated by NF-κB and antiviral activity against many flavivirus and negative-strand RNA viruses through the inhibition of calcium channel. Manidipine is widely applied to research of cardiovascular, metabolic disease and infection.

HY-B1378

Ethosuximide	Inhibitor	99.26%
Ethosuximide, a widely prescribed anti-epileptic agent, improves the phenotypes of multiple neurodegenerative disease models and blocks the low voltage activated T-type calcium channel.

HY-103309

ML218	Inhibitor	99.49%
ML218 is a potent, selective and orally active T-type Ca²⁺ channels (Cav3.1, Cav3.2, Cav3.3) inhibitor with IC₅₀s of 310 nM and 270 nM for Cav3.2 and Cav3.3, respectively. ML218 inhibits the burst activity in subthalamic nucleus (STN) neurons. ML218 has no significant inhibition of L- or N-type calcium channels, K_ATP or hERG potassium channels. ML218 can penetrate the blood-brain barrier.

HY-12502A

Efonidipine hydrochloride monoethanolate	Inhibitor	99.83%
Efonidipine hydrochloride monoethanolate (NZ-105 hydrochloride monoethanolate) is a dual T-type and L-type calcium channel blocker (CCB).

HY-W011235

Norfluoxetine hydrochloride	Inhibitor	99.58%
Norfluoxetine hydrochloride is an active N-demethylated metabolite of Fluoxetine. Fluoxetine is a selective serotonin (5-HT) reuptake inhibitor that is metabolized to Norfluoxetine hydrochloride by cytochrome P450 (CYP) 2D6, CYP2C19, and CYP3A4. Norfluoxetine hydrochloride inhibits 5-HT uptake and inhibits CaV3.3 T current (IC50 = 5 μM). Norfluoxetine hydrochloride has anticonvulsant activity.

HY-A0092

Trimethadione	Inhibitor	≥98.0%
Trimethadione (3,5,5,-Trimethyloxazolidine-2,4-dione) is an oxazolidinedione anticonvulsant agent widely used against absences seizures. Trimethadione also is a T-type calcium channel blocker which has antihyperalgesic effects.

HY-101096

Suvecaltamide	Inhibitor	99.96%
Suvecaltamide (MK-8998) is a selective T-type calcium channel inhibitor with oral efficacy. Suvecaltamide exhibits no cytotoxicity in myeloma cell lines and does not affect the antitumor efficacy of Bortezomib (BTZ). Suvecaltamide reverses BTZ-induced peripheral neuropathy (CIPN) in mouse and rat models, and helps inhibit myeloma growth.

HY-19721

ABT-639	Inhibitor	99.32%
ABT-639 is a novel, peripherally acting, selective T-type Ca²⁺ channel blocker.

HY-W032013

1-Octanol	Inhibitor	99.63%
1-Octanol (Octanol), a saturated fatty alcohol, is a T-type calcium channels (T-channels) inhibitor with an IC₅₀ of 4 μM for native T-currents. 1-Octanol is a highly attractive biofuel with diesel-like properties.

HY-115681

(2R/S)-6-PNG	Inhibitor	99.88%
(2R/S)-6-PNG (6-Prenylnaringenin) is a potent and reversible Ca_v3.2 T-type Ca²⁺ channels (T-channels) blocker. (2R/S)-6-PNG can penetrate the blood-brain barrier (BBB). (2R/S)-6-PNG suppresses neuropathic and visceral pain in mice.

HY-15553

Mibefradil	Inhibitor
Mibefradil (Ro 40-5967) is a calcium channel blocker with moderate selectivity for T-type Ca²⁺ channels displaying IC₅₀s of 2.7 μM and 18.6 μM for T-type and L-type currents, respectively.

HY-150541

IAA65	Inhibitor
IAA65 is a potent T-type calcium channel inhibitor with a IC₅₀ value of 18.9 µM. IAA65 can be used for epilepsy research.

HY-150539

IAB15	Inhibitor
IAB15 is a potent T-type calcium channel inhibitor. IAB15 can be used for epilepsy research.

HY-147638

MONIRO-1	Inhibitor	99.18%
MONIRO-1 is a T-type and N-type calcium channel blocker with IC₅₀ values of 34, 3.3, 1.7 and 7.2 µM against hCa_v2.2, hCa_v3.1, hCa_v3.2 and hCa_v3.3, respectively.

HY-126401

Elgodipine	Inhibitor
Elgodipine (IQB-875 free base) is an orally active dihydropyridine calcium antagonist and an antianginal compound. Elgodipine inhibits both T- and L-type calcium channels (IC₅₀: 32 and 2.3 nM). Elgodipine lowers systemic vascular resistance and improves systolic cardiac function.

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